Circulating vaspin is unrelated to insulin sensitivity in a cohort of non-diabetic humans Short running title: serum vaspin and insulin sensitivity

نویسندگان

  • Christian von Loeffelholz
  • Matthias Möhlig
  • Ayman M Arafat
  • Frank Isken
  • Joachim Spranger
  • Knut Mai
  • Harpal S Randeva
  • Andreas F H Pfeiffer
  • Martin O Weickert
  • Ayman M. Arafat
  • Harpal S. Randeva
  • Andreas F. H. Pfeiffer
  • Martin O. Weickert
چکیده

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Modulation of Serum Vaspin Level by Diet Regimen in Obese Diabetic Female Patients

Obesity was associated with high serum vaspin concentrations and increased vaspin mRNA expression in human adipose tissue , insulin resistance, and type II diabetes. However, the mechanisms how vaspin secretion may be linked to deterioration of glucose metabolism and insulin sensitivity are not understood. The aim of this work is to explore the effect of dietary regimen for 6 months on serum va...

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Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans.

OBJECTIVE To study the association of vaspin with glucose metabolism. DESIGN Cross-sectional and intervention study. SUBJECTS AND METHODS The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers. Euglycemic-hyperinsulinemic clamps (EHC) were performed in 83 of the participants. Changes of circulating vaspin levels were additionally...

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Serum vaspin concentrations in human obesity and type 2 diabetes.

OBJECTIVE Vaspin was identified as an adipokine with insulin-sensitizing effects, which is predominantly secreted from visceral adipose tissue in a rat model of type 2 diabetes. We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabete...

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Resveratrol attenuates visfatin and vaspin genes expression in adipose tissue of rats with type 2 diabetes

Objective(s): Visfatin and vaspin are secreted by adipose tissue and play key roles in glucose homeostasis and subsequently are potential targets for diabetes treatment. Resveratrol (RVS) corrects insulin secretion and improves insulin sensitivity. We investigated the RVS effects on serum antioxidants, insulin and glucose levels, also visfatin and vaspin genes expression in adipose tissue of st...

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The Effect of Eight Weeks of Training and Two Weeks of Detraining in Office on Vaspin and Glycemic Indices of Male Staff

Background and Aim: Adipose tissue is biologically superior to energy storage and an active tissue and secretes proteins such as vaspin, called adipokine. The relationship between fatty tissue and other biological systems of the body is through the expression of some bioactive molecules called adipocytokines. Adipokines are involved in various metabolic processes, including appetite regulation,...

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تاریخ انتشار 2010